For Dr. Anita Bane, her work as a pathologist is both rewarding and intriguing. “It’s kind of like a puzzle,” says the Irish-born physician and PhD scientist. “You use different techniques and look at different aspects of the tissue and cells to get an overall picture of the patient’s disease.” Through a microscope, Dr. Bane gains unique insights that inform decisions related to the treatment and follow-up care for cancer patients. From a research perspective, she is particularly interested in the molecular profile of breast cancer and how this relates to outcome and response to therapy. Additionally, she is studying the clinical significance of breast cancer stem cells, and is in the process of developing testing methods that will enable pathologists to identify specific “markers” for these cells. Dr. Bane plays a leadership role in this field – she is an Ontario Institute for Cancer Research scientist. As part of the Escarpment Cancer Research Institute, she sees an opportunity to build upon a core group of Hamilton-based scientists who are already collaborating. She believes the transfer of knowledge will be enhanced through the establishment of the Institute, and that patients will benefit. “Incremental impacts are very important and our patients need to know that,” says Dr. Bane.
Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy. Bane AL, Whelan TJ, Pond GR, Parpia S, Gohla G, Fyles AW, Pignol JP, Pritchard KI, Chambers S, Levine MN. Ann Oncol. 2014 May;25(5):992-8. doi: 10.1093/annonc/mdu090. Epub 2014 Feb 20.
Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers. Bane A, Viloria-Petit A, Pinnaduwage D, Mulligan AM, O'Malley FP, Andrulis IL. Breast Cancer Res Treat. 2013 Jul;140(1):195-205. doi: 10.1007/s10549-013-2591-1. Epub 2013 Jun 28.
A gene signature for predicting outcome in patients with basal-like breast cancer. Hallett RM, Dvorkin-Gheva A, Bane A, Hassell JA. Sci Rep. 2012;2:227.